Breathe freely all year.
Drug-free nasal spray for pollen: how does a barrier protect against allergens?
Bentrio is a drug-free barrier nasal spray. It lays a thin gel barrier of natural bentonite across the nasal lining that traps pollen, dust mites and pet dander before they reach the immune system. Protection works immediately and lasts up to four hours. No drugs, no preservatives, suitable from age six and during pregnancy. Bentrio was developed in Switzerland.
- Protection per dose
- 4h
- Drugs & preservatives
- Zero
- Suitable from age six
- 6+
Works on contact
No drowsiness, no waiting
- Developed in Switzerland
- Class IIa medical device
- Prescription free
- Safe in pregnancy and breastfeeding
- No drowsiness
- Natural bentonite
- No preservatives
- Up to 4h protection
Act before the first sneeze.
What makes Bentrio different from other allergy products?
Bentrio works one step earlier than most allergy products, which wait for symptoms and then dull them. Bentrio forms its barrier the moment you spray, so allergens are stopped before they ever set symptoms in motion. And if symptoms have already started, that same barrier helps calm and relieve the nose by shielding it from further irritation.
Fast
Starts working immediately on contact – no waiting, no drowsiness, no build-up period.
Powerful
Triple action that shields the nasal mucosa, binds inhaled particles electrostatically and humidifies.
Free
No drugs, no preservatives – formulated with natural bentonite, a mineral found in nature.
Move the pointer to deflect pollen. Tap to add pollen.
Physical protection
A barrier between you and pollen
The gel barrier coats the nasal lining and binds allergens. Schematic illustration, not to scale.
From reacting to symptoms, to blocking them at the door.
Why prevent allergens instead of treating symptoms?
Bentrio prevents contact with allergens instead of quieting a reaction that has already started. It lays down a thin, protective barrier across the nasal lining that intercepts inhaled allergens before the body ever responds.
Think of Bentrio like sunscreen for the nose: a proactive shield you reach for first, not the rescue you reach for last.
Proactive, not reactive
Protects before exposure rather than chasing symptoms.
First-line friendly
A barrier approach suited to mild and moderate allergy sufferers.
Pairs with your routine
Use alone or alongside your existing allergy medication.
Everyday control
Each spray protects for around four hours – simply reapply to stay covered all day outside.
A spray that becomes a shield.
How does Bentrio work inside the nose?
Bentrio is a barrier nasal spray: it lays a gel barrier of natural bentonite across the nasal lining that traps allergens before the immune system reacts. Unlike antihistamines or corticosteroids, it works purely physically, with no pharmacological active ingredient.
Bentrio is a unique nasal spray gel with clinical proof of efficacy in protecting against allergens such as grass pollen and house dust mites. It provides physical protection – without the typical side effects associated with drug-based solutions.
Bentrio transitions from a spray gel to a liquid for easy, comfortable application, then creates a protective gel barrier on the nasal lining that effectively shields against allergens.
Mode of action
Video not loading? Watch directly on Vimeo (English).- 01
Spray gel
In the bottle, Bentrio is a thixotropic* gel. A few firm shakes turn it into a sprayable liquid.
- 02
Becomes liquid
On release it transitions to a fine liquid mist, ensuring an easy and comfortable nasal application.
- 03
Forms a barrier
Inside the nose it sets into a protective gel barrier across the lining, shielding against allergens.
* Thixotropy describes a gel's ability to turn temporarily fluid under mechanical force – here, the shaking – and to set back into a gel when at rest. This switch is what makes Bentrio sprayable and lets it re-form as an adhering barrier on the nasal lining.
One spray. Three ways it protects.
What does bentonite do in a nasal spray?
Bentrio is formulated with bentonite – a naturally occurring mineral whose negatively charged layers attract and hold particles.
Shields
Bentrio forms a thin physical barrier across the nasal mucosa, blocking contact between allergens and the immune system.
Binds electrostatically
The bentonite layers carry a negative surface charge. It attracts inhaled particles – pollen, dust mites and pet dander – and holds them at the surface.
Humidifies
Bentrio moisturises the nasal lining and supports its natural defences, leaving a gentle vanilla scent behind.
What do the clinical data on Bentrio show?
In the randomised NASAR trial, participants applied either Bentrio or a saline solution three times daily for two weeks. Bentrio significantly reduced the mean daily reflective total nasal symptom score (rTNSS) compared with saline (p = 0.013) and improved disease-related quality of life (RQLQ) highly significantly (p < 0.001). Safety and tolerability were comparable to the saline control.
All studies for professionalsSet it up once, then it takes seconds.
How do you use Bentrio correctly?
Bentrio is for adults and children from age six. It works right away and keeps going for up to four hours – top up whenever you need to.
Getting the pump ready
- 1
Press and hold the pump.
- 2
Keeping the pump pressed, shake the bottle firmly up and down five times.
- 3
Release the pump. Then press it every couple of seconds towards a tissue until an even spray comes out.
- 4
If an even spray does not come out, repeat the preparation steps.
Using Bentrio
- 1
Tilt your head slightly forward. Hold the bottle upright and insert the tip just inside one nostril.
- 2
Breathe in gently and press the pump once. Do not sniff afterwards.
- 3
Repeat in the other nostril.
- 4
Wipe the tip and replace the cap. The gel spreads on its own.
Use Bentrio on its own or alongside your other allergy medication. Using another nasal spray too? Take that one first and give it a few minutes before Bentrio.
How does a barrier spray differ from other allergy treatments?
Bentrio belongs to the barrier category, which works physically rather than pharmacologically. That is exactly where the differences come from: protection from the first spray, no active ingredients, no systemic effect – and suitable for children from age six as well as during pregnancy and breastfeeding. The table compares the categories, not individual brands.
| Criterion | Barrier spray (Bentrio) | Oral antihistamine | Corticosteroid nasal spray | Saline solution |
|---|---|---|---|---|
| Mode of action | physical | pharmacological | pharmacological | physical |
| Onset of action | on contact | approx. 30–60 minutes | days to full effect | immediate |
| Active ingredients | none | yes | yes | none |
| Systemic effect | none | yes | low | none |
| Drowsiness possible | no | possible | rare | no |
| In pregnancy and breastfeeding | suitable | ask a doctor | ask a doctor | suitable |
| Preservatives | none | none | often | varies |
| Dosing | as needed, up to 8× daily | fixed daily dose | continuous daily therapy | as needed |
| Protection per application | up to 4 hours, repeatable | approx. 24 hours | with regular use | short |
| Suitable from | age 6 | varies | varies | varies |
| Prescription required | no | sometimes | sometimes | no |
These entries describe each product category; individual products may differ. Corticosteroid nasal sprays act mainly locally and are absorbed systemically only to a small degree. Bentrio is not a replacement for treatment prescribed by a doctor – do not stop prescribed medication without medical advice.
Made for clean sport.
Can athletes use Bentrio without breaking anti-doping rules?
Bentrio protects through a purely physical gel barrier – no drugs, steroids or antihistamines, and no systemic effect on the body. That makes it suitable for competitive athletes who need clear airways without compromising clean-sport rules.
Drug-free mode of action
A mechanical barrier that traps allergens on contact, with no pharmacological effect on the body.
Tested for banned substances
Screened for drugs and substances on anti-doping lists, so it fits within clean-sport requirements.
Chosen by competitive athletes
Used in training and competition by athletes who cannot risk their airways or their eligibility.
What do users report about Bentrio?
My son suffers badly from hay fever. Since switching to Bentrio, the cortisone spray stays in the drawer – he's protected without any medication at all.
CC.H.Parent Normally I'd sneeze constantly outdoors this time of year. After my daily walk with Bentrio, I had no reaction for the rest of the day – just a pleasant vanilla scent.
AA.H.Daily walker Even on allergy tablets the early blossom was rough. A colleague recommended Bentrio and it's been transformative – my runny nose has noticeably calmed despite high pollen.
MM.W.Verified user Years of allergies and sinusitis, and I'd tried everything. With Bentrio I finally reduced the irritation of my mucous membranes. The effect is genuinely noticeable.
DDr. A.Physician
Superior in the ways that matter.
Who is Bentrio suitable for – and who should avoid it?
No drugs, no preservatives
Bentrio is formulated with natural bentonite. No pharmacological, immunological or metabolic effects.
Protection for up to 4 hours
Bentrio is clinically shown to shield against airborne pollen for hours per application.
Suitable in pregnancy
Bentrio is gentle enough for use during pregnancy and breastfeeding, and from age six.
Developed in Switzerland
Bentrio was developed in Switzerland and is manufactured to the highest standards in Europe.
Certified Class IIa (MDR)
Certified under EU MDR 2017/745 (CE 2797) – clinically tested and well tolerated.
Prescription free
Bentrio is available without a prescription, with a well-established safety profile.
Bentrio should not be used if you are hypersensitive to any of its ingredients, or if you have open wounds or an injury inside the nose. If you are unsure whether Bentrio suits you, ask your doctor or pharmacist.
Quality you can see being made.
Where is Bentrio manufactured?
Bentrio was developed in Switzerland and is manufactured at NextPharma in Germany – one of Europe's most respected pharmaceutical producers. Watch how every bottle is filled and checked under exacting standards.
Made in Germany
Produced at our manufacturing partner NextPharma, a trusted European pharmaceutical specialist.
GMP-certified production
Every batch is filled under strict Good Manufacturing Practice and pharmaceutical-grade quality control.
Built to medical standards
Manufactured as a certified Class IIa medical device, traceable from raw material to finished bottle.
Questions, answered.
What do people ask most about Bentrio?
Everything you might want to know before your first spray. Still curious? Reach out and we'll happily help.
How does Bentrio work?
Bentrio protects the nasal lining in three ways: it humidifies the mucosa and supports its natural function, binds inhaled particles electrostatically through the negatively charged bentonite layers, and shields the mucosa with a thin physical barrier.
What are the main ingredients? Is it safe?
Bentrio is formulated with bentonite, a naturally occurring mineral known for its strong absorption capacity. It is free from preservatives to reduce the risk of irritation, and its ingredients have a well-established safety profile. It should not be used if you are hypersensitive to any ingredient or have open wounds or injury inside the nose.
Why is it a gel-emulsion?
The gel-emulsion form helps Bentrio stay in the nose longer and stay effective. It has been shown to protect against airborne pollen for hours after application.
What does it smell like?
Bentrio contains vanillin, so it releases a gentle, pleasant vanilla scent on application.
Can I use it with other allergy medication?
Yes, Bentrio can be used on its own or alongside other allergy treatments. Because it works physically rather than pharmacologically, it does not interact with antihistamines or corticosteroid sprays. If you use another nasal spray, apply that first and wait a few minutes before using Bentrio.
Who can use Bentrio?
Bentrio is suitable for adults and children from age six, and is suitable for use during pregnancy and breastfeeding.
Is Bentrio safe during pregnancy and breastfeeding?
Yes, Bentrio is suitable for use during pregnancy and breastfeeding. It contains no pharmacological active ingredients and works purely physically, forming a barrier on the nasal lining rather than entering the bloodstream. If you have questions about your individual situation, speak to your doctor or pharmacist.
From what age can children use Bentrio?
Bentrio is suitable for children from the age of six. The application is the same as for adults: one spray into each nostril, repeated when needed. Younger children should be supervised the first few times so that the spray is applied correctly.
What is bentonite and is it safe?
Bentonite is the naturally occurring mineral that Bentrio is formulated with, and it has a well-established safety profile. It is a clay mineral with an exceptional ability to absorb and hold particles, which is what allows Bentrio to trap allergens at the surface of the nasal lining. It stays on the mucosa and has no pharmacological, immunological or metabolic effect.
How often a day can I use Bentrio?
Bentrio can be used up to eight times a day. Within that limit, use it as often as you need.
How long does Bentrio keep after opening?
Once opened, Bentrio can be used for six months. It helps to note the date you opened it so you can keep track of that period.
When and where will Bentrio be available?
Bentrio is not yet available for sale, and no launch date has been confirmed. Availability will roll out country by country in line with local regulatory and distribution requirements. With more partners across various markets, our aim is to make Bentrio available worldwide. If you would like to hear from us when that changes, get in touch and we will keep you posted.
Questions about Bentrio? We're here to help.
Bentrio was developed in Switzerland. Talk to our AI assistant for instant answers, or reach the team directly. For partnership and licensing enquiries, our business development team is ready to connect.
Altamira Medica AG
Peter Merian-Strasse 90, 4052 Basel, Switzerland
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